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ARCA Cap Analog
Stabilizing Triphosphate which enhance the RNA Transfection
- Size
- Catalog No.
- Price
- 0.5 µmol
BCT-24-S
- € 75,00
- 2.5 µmol
BCT-24-M
- € 250,00
- 5.0 µmol
BCT-24-L
- € 380,00
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One key advancement to develop so-called drugable mRNAs was the preparation of chemically modified mRNAs, e.g. by capping. The introduction of modified nucleobases such as Anti-Reverse Cap Analog (ARCA) was the foundations for clinical usage of mRNAs. The half-life of the mRNA and the translation efficiency is increased by using this cap analog used during in vitro transcription for the generation of capped transcripts.
LITERATURE
Jemielity et al., RNA, 2003, 9:1108
Peng et al., Org. Lett., 2002, 4(2):161
Stepinski et al., RNA, 2001, 7:1486
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Molecular Formula
C22H31N10O18P3
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C
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Molecular Weight
816.46 g/mol
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Purity
≥ 98 % (HPLC)
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Physical State
100 mM clear aquaeous solution; colorless
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CAS Number
400806-46-4 (acid),
400806-60-2 (sodium salt) -
Absorption (max)
λmax = 255 nm
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Ɛ (max)
22,600 cm-1M-1
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Molecular Formula