ARCA (Anti-Reverse Cap Analog)
Cap Analog
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ARCA (Anti-Reverse Cap Analog) modified mRNA exhibits a longer half-life and the translation efficiency is increased by using this cap analog used during in vitro transcription for the generation of capped transcripts.
LITERATURE
Novel “anti-reverse” cap analogs with superior translational properties, J. Jemielity et al., 2003, RNA, Vol. 9, p. 1108-1122.
https://doi.org/10.1261/rna.5430403
Synthesis and Application of a Chain-Terminating Dinucleotide mRNA Cap Analog, Z. Peng et al., 2002, Org. Lett., Vol. 4(2), p. 161-164.
https://doi.org/10.1021/ol0167715
5-Ethynyluridine: A Bio-orthogonal Uridine Variant for mRNA-Based Therapies and Vaccines, S. Maassen et al., 2023, ChemBioChem, Vol. 24(5), e202200658.
https://doi.org/10.1002/cbic.202200658
Chemoenzymatic Preparation of Functional Click-Labeled Messenger RNA, S. Croce et al., 2020, ChemBioChem, Vol. 21(11), p. 1641-1646.
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Molecular Formula
C22H31N10O18P3
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C
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Molecular Weight
816.46 g/mol
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Purity
≥ 98% (HPLC)
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Physical State
100 mM clear aquaeous solution; colorless
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CAS Number
400806-46-4 (acid),
400806-60-2 (sodium salt) -
Absorption (max)
λmax = 255 nm
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Ɛ (max)
22,600 cm-1M-1
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Additional name
m27,3′-OGP3G; m27,3′-OG(5′)ppp(5′)G; P1-(5′-(3′-O-methyl)-7-methyl-guanosyl) P3-(5′-(guanosyl))triphosphate, Sodium salt
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Molecular Formula