We enable nucleic acid labeling bioconjugation
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ARCA Cap Analog

Stabilizing Triphosphate which enhance the RNA Transfection

Currency:  
  • Size
  • Catalog No.
  • Price
  • 0.5 µmol
  • BCT-24-S

  • € 75,00
  • 2.5 µmol
  • BCT-24-M

  • € 250,00
  • 5.0 µmol
  • BCT-24-L

  • € 380,00
Clear
  • One key advancement to develop so-called drugable mRNAs was the preparation of chemically modified mRNAs, e.g. by capping. The introduction of modified nucleobases such as Anti-Reverse Cap Analog (ARCA) was the foundations for clinical usage of mRNAs. The half-life of the mRNA and the translation efficiency is increased by using this cap analog used during in vitro transcription for the generation of capped transcripts.

    LITERATURE

    Jemielity et al., RNA, 2003, 9:1108

    Peng et al., Org. Lett., 2002, 4(2):161

    Stepinski et al., RNA, 2001, 7:1486

    • Molecular Formula

      C22H31N10O18P3

    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C

    • Molecular Weight

      816.46 g/mol

    • Purity

      ≥ 98 % (HPLC)

    • Physical State

      colorless solution

    • CAS Number

      400806-46-4 (acid),
      400806-60-2 (sodium salt)

    • Absorption (max)

      λmax = 255 nm

    • Ɛ (max)

      22,600 cm-1M-1