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C8-Alkyne-dC-CEP
Clickable Oligo Synthesis Building Block
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This special DNA phosphoramidite with a C8-Spacer between the reactive alkyne group and the backbone is used under standard conditions for solid phase synthesis of oligonucleotides. It has shown to be incorporated into DNA oligomers with excellent coupling efficiency and subsequent use of those oligonucleotides in click reactions is achieved using our different azide labels.
LITERATURE
P. M. E. Gramlich, S. Warncke, J. Gierlich, T. Carell, Angew. Chemie – Int. Ed. 2008, 47, 3442–3444.
P. M. E. Gramlich, C. T. Wirges, A. Manetto, T. Carell, Angew. Chemie – Int. Ed. 2008, 47, 8350–8358.
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Molecular Formula
C54H60N5O8P
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C dry, inert gas
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Molecular Weight
938.06 g/mol
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Purity
≥ 95% (31P NMR)
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Physical State
white to off-white solid
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CAS Number
1021300-97-9
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Additional name
4-N-Benzoyl-5-(octa-1,7-diynyl)-3´-O-[(2-cyanoethoxy)(diisopropylamino)-phosphono)]-5´-O-(4,4´-dimethoxytrityl)-2’-deoxycytidine
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Preparation/Handling
This phosphoramidite is used under standard conditions for solid phase synthesis of oligonucleotides.
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Molecular Formula