We enable nucleic acid labeling bioconjugation
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C8-TMS-dC-CEP

Clickable Oligo Synthesis Building Block

Currency:  
  • Size
  • Catalog No.
  • Price
  • 250 mg
  • BCA-04-250

  • € 105,00
  • 1.0 g
  • BCA-04-1g

  • € 340,00
  • 5.0 g
  • BCA-04-5g

  • € 1.600,00
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  • This unique DNA phosphoramidite with a C8-Spacer between the clickable group and the backbone is used under standard conditions for solid phase synthesis of oligonucleotides. It has shown to be incorporated into DNA oligomers with good coupling efficiency. The protection group on the alkyne can be exploited to introduce different labels by click chemistry into one oligo. Having reacted a first group and purified the compound, the TMS can then be deprotected and is thus ready for a second click reaction with another click azide on the same product.

    LITERATURE

    P. M. E. Gramlich, S. Warncke, J. Gierlich, T. Carell, Angew. Chemie – Int. Ed. 2008, 47, 3442–3444.

    P. M. E. Gramlich, C. T. Wirges, A. Manetto, T. Carell, Angew. Chemie – Int. Ed. 2008, 47, 8350–8358.

    • Molecular Formula

      C57H68N5O8PSi

    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20°C dry, inert gas

    • Molecular Weight

      1010.24 g/mol

    • Purity

      ≥95% (HPLC)

    • Physical State

      white to off-white solid

    • CAS Number

      n.a.

    • Additional name

      4-N-Benzoyl-5-(8-trimethylsilyl-octa-1,7-diynyl)-3`-O-[(2-cyanoethoxy)(diisopropylamino)-phosphono)]-5`-O-(4,4`-dimethoxytrityl)-2`-deoxycytidine

    • Preparation/Handling

      This phosphoramidite is used under standard conditions for solid phase synthesis of oligonucleotides.

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