mRNA Configurator - baseclick GmbH

Welcome to our mRNA Configurator section!

Click technology holds the promise to revolutionize the mRNA Technology in drug development for cancer treatment, vaccine discovery and enables tailored manufactured mRNA with superior quality.

Since 2022, baseclick is guiding provider in custom messenger in vitro mRNA synthesis and modification for research and clinical applications. Our team of experts transforms your mRNA design ranging from research tool to mRNA product development.

baseclick supplies diverse types of mRNA

High quality products and services at competitive prices
Custom tailored support to meet specific applications
Wide variety of modification
Affordable custom synthesis up to 10 mg scales of mRNA

LITERATURE

Chemoenzymatic Preparation of Functional Click-Labeled Messenger RNA, S. Croce et al., 2020, ChemBioChem, Vol. 21, p. 1641.

https://doi.org/10.1002/cbic.201900718

5-Ethynyluridine: a bio-orthogonal uridine variant for mRNA-based therapies and vaccines, S. Maassen et al., 2023, ChemBioChem, Vol. 24, p. e202200658.

https://doi.org/10.1002/cbic.202200658

We offer three categories of custom made mRNA from un-modified to diverse modified mRNA:

RNA Name

Template Source

DNA Length

RNA Length

Template Type

To proceed with your request, it is required that your template contains a T7 promoter site. Please provide the sequence of the three bases immediately after the T7 promoter:

Full Sequence

Upload a file (Textfile (txt, Word), FASTA)

5’ Capping

CleanCap AG requires the initiation sequence 5’ AGG 3’ ARCA Cap Analog requires the initiation sequence 5’ GG 3’

Phosphatase Treatment

Uracil Modifications

Poly(A) Tail

Enzyme for Linearization

Buffer

3’ Modification via 3’-Azido-ddATP

Click Conjugation at 3’end

Yield

Purity by A260/A280 ratio and Integrity by denaturing Agarose Gel

Report

+ Add another Transcript

RNA Name

Template Source

DNA Length

RNA Length

Template Type

To proceed with your request, it is required that your template contains a T7 promoter site. Please provide the sequence of the three bases immediately after the T7 promoter:

Full Sequence

Upload a file (Textfile (txt,Word), FASTA, GeneBank)

5’ Capping

CleanCap AG requires the initiation sequence 5’ AGG 3’ ARCA Cap Analog requires the initiation sequence 5’ GG 3’

Phosphatase Treatment

Uracil Modifications

Poly(A) Tail

Enzyme for Linearization

Buffer

3’ Modification via 3’-Azido-ddATP

Click Conjugation at 3’end

Yield

Purity by A260/A280 ratio and Integrity by denaturing Agarose Gel

Report

+ Add another Transcript

RNA Name

Template Source

DNA Length

RNA Length

Template Type

To proceed with your request, it is required that your template contains a T7 promoter site. Please provide the sequence of the three bases immediately after the T7 promoter:

Full Sequence

Upload a file (Textfile (txt,Word), FASTA, GeneBank)

5’ Capping

CleanCap AG requires the initiation sequence 5’ AGG 3’ ARCA Cap Analog requires the initiation sequence 5’ GG 3’

Phosphatase Treatment

Uracil Modifications

Poly(A) Tail

Enzyme for Linearization

Buffer

3’ Modification via 3’-Azido-ddATP

Click Conjugation at 3’end

Yield

Purity by A260/A280 ratio and Integrity by denaturing Agarose Gel

Report

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