baseclick, the leading force in Nobel Prize winning Click Chemistry – the story

In the late 1990s, Click Chemistry has been discovered by Prof. Dr. Morten Meldal and Prof. Dr. Barry Sharpless as the fundament for Bioorthogonal Chemistry. Later on, Prof. Dr. Carolyn Bertozzi added an important step by developing click chemistry towards copper free applications, which revolutionized the use of click chemistry in and on life cells.

“This breakthrough research was awarded with the Nobel Prize for Chemistry in 2022”.

 In 2006, Prof. Dr. Thomas Carell published his first paper on click chemistry by using the original copper-catalysed version of click chemistry to combine DNA with sugar molecules. This was followed by several other publications and inventions in the field of click chemistry for nucleic acid modification which have paved the way to successfully commercialize click chemistry.

In 2008, BASF Company recognized the enormous future potential of utilizing the click chemistry concept for bioconjugation of nucleic acids and founded baseclick GmbH together with Prof. Dr. Thomas Carell.

baseclick under the leadership of Dr. Thomas Frischmuth in cooperation with Prof. Dr. Carell and his group at the Ludwig-Maximilians University Munich (LMU), has established a broad portfolio of click chemistry reagents and various click chemistry kits for EdU-based cell proliferation assay, oligonucleotide modification chemistry, click-based FISH technologies as well as PCR based diagnostic applications, to name a few. Recently baseclick also developed a kit for massive parallel sequencing, the so-called next generation sequencing of second/third-generation. This portfolio is protected by the most comprehensive set of patents in the field.

baseclick’s Licensees and Distributors have introduced these products and services successfully into the market making baseclick today the leading force in enabling new click chemistry solutions and products.

DNA and RNA applications in click chemistry have been a part of baseclick’s offer to the research community for quite a long time. The recent movement towards mRNA, siRNA and antisense oligonucleotides R&D and the potential role of click chemistry in these fields, now opens new and highly promising perspectives for baseclick and its partners.

baseclick GmbH now offers access to its know-how and IP to researchers and industry partners in Pharma and Vaccine R&D through enlarged RNA / DNA services, high profile consulting and cooperation’s with Industry.

Our highlights

• Click chemistry in oligonucleotide synthesis enables labeling up to 99.99% yield.
• The most versatile click chemistry portfolio of chemical tools including clickable dyes, sugars, fatty acids, amino acids, biotin and more to advance innovative projects
• Our EdU cell proliferation assays provide a superior alternative to BrdU assays. For monitoring of cell vitality, determining genotoxicity or evaluating anticancer drugs.
• Our technology enables 5’, 3’, dual, multi or internally labeled DNA or RNA sequences used in our FISH Kits and PCR Kits.
• Click chemistry in Next Generation Sequencing enables-for the first time – complete full-length information from 5’ to 3’ in transcriptomics and is compatible with all available sequencing devices.

Our lab expertise in click chemistry of nucleic acid drug and vaccine development is also available as a service

• Our specialized custom oligonucleotide service to produce drug substances like aptamers, siRNA and more
• Specific cellular uptake can be achieved with mRNA clicked to targeting agents and generated via our mRNA production service