We enable nucleic acid labeling bioconjugation
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Innovation is the engine that drives us

Our mission is to provide the best nucleic acid labeling applications and reagents for the life science market.
To accomplish this we continuously strive to develop new and easier ways to connect biomolecules using the best possible conditions.
Please check out our publications to inform yourself about our advancements in the life science sector.

2023

Orthogonal End Labelling of Oligonucleotides through Dual Incorporation of Click-Reactive NTP Analogues, E. S. Schönegger et al., 2023, ChemBioChem, e202300701.

https://doi.org/10.1002/cbic.202300701

Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage, C. Beck et al., 2023, Nature Communications, Vol. 14, 4564.

https://doi.org/10.1038/s41467-023-40185-1

5-Ethynyluridine: A Bio-orthogonal Uridine Variant for mRNA-Based Therapies and Vaccines, S. Maassen et al., 2023, ChemBioChem, Vol. 24(5), e202200658.

https://doi.org/10.1002/cbic.202200658

Divergent Synthesis of Ultrabright and Dendritic Xanthenes for Enhanced Click-Chemistry-Based Bioimaging, L. Montiel et al., 2023, Chemistry – A European Journal, Vol. 29(5), e202202633.

https://doi.org/10.1002/chem.202202633

 

2022

Click Chemistry Enables Rapid Amplification of Full-Length Reverse Transcripts for Long-Read Third Generation Sequencing, E. S. Schönegger et al., 2022, Bioconjugate Chem., Vol. 33(10), p. 1789–1795.

https://doi.org/10.1021/acs.bioconjchem.2c00353

 

2020

Chemoenzymatic Preparation of Functional Click-Labeled Messenger RNA, S. Croce et al., 2020ChemBioChem, Vol. 21(11), p. 1641-1646.

https://doi.org/10.1002/cbic.201900718

Supersensitive Multifluorophore RNA-FISH for Early Virus Detection and Flow-FISH by Using Click Chemistry, N. Raddaoui et al., 2020, ChemBioChem, Vol. 21(15), p. 2214-2218.

https://doi.org/10.1002/cbic.202000081

Efficient DNA Click Reaction Replaces Enzymatic Ligation, M. Kollaschinski et al., 2020, Bioconjugate Chem., Vol. 31(3), p. 507–512.

https://doi:10.1021/acs.bioconjchem.9b00805

 

2018

Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures, I. Manuguerra et al., 2018, Chem. Commun., Vol. 54(36), p. 4529-4532.

https://doi.org/10.1039/C8CC00738A

 

2015

One-Step Formation of “Chain-Armor”-Stabilized DNA Nanostructures, V. Cassinelli et al., 2015, Angewandte Chemie, Vol. 54(27), p. 7795-7798.

https://doi.org/10.1002/anie.201500561

 

2012

Oligothiophenes as Fluorescent Markers for Biological Applications, M. L. Capobianco et al., 2012, Molecules, Vol. 17(1), p. 910–933.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268780/

 

2011

Ambivalent effects of defective DNA in beet curly top virus-infected transgenic sugarbeet plants, J. Horn et al., 2011, Virus Research, Vol. 158(1-2), p. 169-178.

https://doi.org/10.1016/j.virusres.2011.03.029

 

2010

A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica, A. Schlossbauer et al., 2010, Angewandte Chemie, Vol. 49(28), p. 4734-4737.

https://doi.org/10.1002/anie.201000827

 

2008

Postsynthetic DNA Modification through the Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction, P. M. E. Gramlich et al., 2008, Angewandte Chemie, Vol. 47(44), p. 8350-8358.

https://doi.org/10.1002/anie.200802077