We enable nucleic acid labeling and bioconjugation

At baseclick we believe that bioconjugation is not just a method to connect (bio)molecules, but a tool to develop valuable applications.
Simple methods for efficient and robust nucleic acid labeling are at the core of the baseclick technology.
Our mission is to develop and provide the best nucleic acid labeling applications and reagents for the life science market.

baseclick – the History

In the late 1990s, Click Chemistry has been discovered by Prof. Dr. Morten Meldal and Prof. Dr. Barry Sharpless as the fundament for Bioorthogonal Chemistry. Later, Prof. Dr. Carolyn Bertozzi added an important step by developing click chemistry towards copper free applications, which revolutionized the use of click chemistry in and on life cells.

In 2006, Prof. Dr. Thomas Carell, chair of organic chemistry Ludwig-Maximillians-University, published his first paper on click chemistry by using the original copper-catalyzed version of click chemistry to combine DNA with fluorescence dyes. This was followed by several other publications and inventions in the field of click chemistry for nucleic acid modification which have paved the way to successfully commercialize click chemistry.

In 2008, BASF Company recognized the enormous future potential of utilizing the click chemistry concept for bioconjugation of nucleic acids and founded baseclick GmbH together with Prof. Dr. Thomas Carell.

In 2009, Dr. Thomas Frischmuth became managing director of baseclick GmbH and developed the first products and brought them to the market.

In 2022, Prof. Dr. Carolyn Bertozzi, Prof. Dr. Morten Meldal and Prof. Dr. Barry Sharpless were awarded with the “Nobel Prize for Chemistry”.

Scientists at baseclick and elsewhere are improving the technology and widening its scope by creating inventive applications and have established together a broad portfolio of click chemistry reagents and various kit systems for EdU-based cell proliferation assay, oligonucleotide modification, click-based FISH technologies as well as PCR based diagnostic applications, to name a few. Recently baseclick also developed a kit for massive parallel sequencing, the so-called next generation sequencing of second/third generation. This portfolio is protected by the most comprehensive set of patents in the field.

baseclick’s Licensees and Distributors have introduced these products and services successfully into the market making baseclick today the leading force in enabling new click chemistry solutions and products.

Our expertise in this field offers access to its know-how and IP to researchers, laboratories, life science and industry partners in Pharma and Vaccine R&D through enlarged RNA / DNA services, high profile consulting and cooperation’s with Industry. The recent movement towards mRNA, siRNA and antisense oligonucleotides R&D and the potential role of click chemistry in these fields, now opens new and highly promising perspectives for baseclick and its partners.

One Reaction Type – Various Applications

Our versatile bioconjugation method has shown its superiority in various segments such as

• EdU cell proliferation assays
• Custom modified oligonucleotides
• Reagents and labels for click chemistry
• Aptamer research
• (m)RNA research
• Peptide and protein labeling
• Additional tools for purification, staining and transfection

Find more information about our applications on the technology page and discover our products in our online shop or simply contact us.