With 7-Ethynyl-dA-CE Phosphoramidite it is possible to introduce alkyne modified A in the oligonucleotide. After standard solid phase synthesis, the final oligo is ready for subsequent click reaction.

LITERATURE

Rational design, synthesis, and photophysics of dual-emissive deoxyadenosine analogs, H. N. Le et al., 2019, Dyes and Pigments, Vol. 170, p. 107553.

https://doi.org/10.1016/j.dyepig.2019.107553

Nucleotides and nucleic acids; oligo-and poly-nucleotides, D. Loakes, 2014, In Organophosphorus Chemistry, p. 146-245.

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