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DBCO-C6-Alkyne

Bifunctional linker

Size Catalog No. Price
5 mg BCL-035-5 € 80,00
10 mg BCL-035-10 € 130,00
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  • The heterobifunctional linker DBCO-C6-Alkyne contains an Alkyne and a DBCO moiety which enable the possibility to perform two sequential click reactions in an orthogonal way. Therefore this linker offers a great potential to cross link to azide containg biomolecules by just using high efficient Click Chemistry. There is also the possibility to selectively click the alkyne before the DBCO [1]. Therefore this linker offers great potential for the synthesis of Antibody-drug-conjugates (ADC).

     

    LITERATURE

    [1] Transient protection of strained alkynes from click reaction via complexation with copper, S. Yoshida et al., 2014, Journal of the American Chemical Society, Vol. 136(39), p. 13590-13593.

    https://doi.org/10.1021/ja507660x

    • Molecular Formula

      C24H22N2O2

    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C, dark

    • Molecular Weight

      370.45 g/mol

    • Purity

      ≥ 95% (HPLC)

    • Physical State

      white to off-white solid

    • CAS Number

      n.a.

    • Additional name

      N-(propargylamidoadipoyl)-dibenzoazacyclooctyne

    • Solubility

      DMSO, DMF, DCM, THF, Chloroform

    • Preparation/Handling

      For a 10 mM solution add 1350 μL to 5 mg.
      For a 10 mM solution add 2699 μL to 10 mg.

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