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DBCO-PEG4-DBCO

Homobifunctional linker

Size Catalog No. Price
5 mg BCL-039-5 € 90,00
10 mg BCL-039-10 € 140,00
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  • The homo bifunctional linker DBCO-PEG4-DBCO contains two DBCO moieties which enable reaction with two azides. This linker is well suited for cross linking when used in excess [1,2] but enables other interesting possibilities as circularization of biomolecules containing two azides. The hydrophilic PEG4 spacer increase water solubility needed for reaction with biomolecules in aqueous media.

     

    LITERATURE

    [1] Generation of therapeutic protein variants with the human serum albumin binding capacity via site-specific fatty acid conjugation, J. Cho et al., 2017, Scientific Reports, Vol. 7(1), 18041.

    https://doi.org/10.1038/s41598-017-18029-y

    [2] An expanded genetic code facilitates antibody chemical conjugation involving the lambda light chain, A. Kato et al., 2021, Biochemical and Biophysical Research Communications, Vol. 546, p. 35-39.

    https://doi.org/10.1016/j.bbrc.2021.02.005

    Characterization and scaled-up production of azido-functionalized silk fiber produced by transgenic silkworms with an expanded genetic code, H. Teramoto et al., 2019, International Journal of Molecular Sciences, Vol. 20(3), 616.

    https://doi.org/10.3390/ijms20030616

    • Molecular Formula

      C48H50N4O8

    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C, dark, dry

    • Molecular Weight

      811 g/mol

    • Purity

      ≥ 95% (HPLC)

    • Physical State

      white to light yellow powder

    • CAS Number

      2182601-68-7

    • Solubility

      DMSO, MeOH, DMF

    • Preparation/Handling

      For a 10 mM solution add 123 μL per 1 mg.

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