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DBCO-PEG4-NHS ester

Bifunctional linker

Size Catalog No. Price
5 mg BCL-038-5 € 70,00
10 mg BCL-038-10 € 110,00
50 mg BCL-038-50 € 450,00
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  • The bifunctional linker DBCO-PEG4-NHS ester contains a DBCO and a NHS ester moiety which allows to crosslink azide containing compounds with compounds bearing primary amines without the need of a catalyst. The introduction of the hydrophilic PEG4 spacer reduces aggregation and precipitation during the labeling reaction and also minimizes steric hindrance between the conjugate.

     

    LITERATURE

    Equipping natural killer cells with cetuximab through metabolic glycoengineering and bioorthogonal reaction for targeted treatment of KRAS mutant colorectal cancer, X. Wang et al., 2021, ACS Chemical Biology, Vol. 16(4), p. 724-730.

    https://doi.org/10.1021/acschembio.1c00022

    Enzyme‐Based Synthetic Protein Nanoparticles as Colloidal Antioxidants, A. Mauser et al., 2023, Advanced Therapeutics, 2300007.

    https://doi.org/10.1002/adtp.202300007

    Construction of artificial cilia from microtubules and kinesins through a well-designed bottom-up approach, R. Sasaki et al., 2018, Nanoscale, Vol. 10(14), p. 6323-6332.

    https://doi.org/10.1039/C7NR05099B

    • Molecular Formula

      C34H29N3O10

    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C, dark, dry, protective gas

    • Molecular Weight

      649.7 g/mol

    • Purity

      ≥ 95% (HPLC)

    • Physical State

      white to light yellow powder

    • CAS Number

      1427004-19-0

    • Additional name

      DBCO-PEG4-succinimidyl Ester, 2,5-Dioxo-1-pyrrolidinyl 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo-4,7,10,13-tetraoxa-16-azaeicosanoate
      Dibenzocyclooctyne-PEG4-succinimidyl Ester

    • Solubility

      DMSO, DCM, DMF

    • Preparation/Handling

      For a 10 mM solution add 154 μL per 1 mg.

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