NHS-C3-Azide

This hetero-bifunctional reagent allows to crosslink alkyne (bio-)molecules to compounds bearing primary amines. The NHS ester group will react covalently with primary amines while the azide can undergo click reaction in catalyzed conditions with terminal alkynes. This linker is often used to introduce azide moieties into amino-oligonucleotides after solid phase synthesis.

LITERATURE

W. Hou, Y. Li, W. Kang, X. Wang, X. Wu, S. Wang, F. Liu, Scientific Reports, 2019, 9, 1307

A.E. Kuznetsov, N. V. Komarova, E. V. Kuznetsov, M. S. Andrianova, V. P. Grudtsov, E. N. Rybachek, K. V. Puchnin, D. V. Ryazantsev, A. N. Saurov, Biosensors and Bioelectronics,
2019, 129, 29-35

P. Kumar, F. M. Kuhlmann, S. Chakroborty, A. L. Bourgeois, J. Foulke-Abel, B. Tumala, T. J. Vickers, D. A. Sack, B. DeNearing, C. D. Harro, W. S. Wright, J. C. Gildersleeve, M. A. Ciorba, S. Santhanam, C. K. Porter, R. L. Gutierrez, M. G. Prouty, M .S. Riddle, A. Polino, A. Sheikh, M. Donowitz, J. M. Fleckenstein, The Journal of clinical investigation, 2018, 128(8), 3298-3311

M. Andrianova, N. Komarova, V. Grudtsov, E. Kuznetsov, Sensores, 2018, 18, 49

A. Kuznetsov, N. Komarova, M. Andrianova, V. Grudtsov, E. Kuznetsov, Microchimica Acta, 2018, 185(1), 3

M. Taskova, L. Miotke, M. Kubit, J. Bell, H. P. Ji, K. Astakhova, Analytical Chemistry, 2017, 89(8), 4363–4366

J. Bu, A. L. Pilo, S. A. McLuckey, International Journal of Mass Spectrometry, 2015, 309, 118-123

I. Potapova, D. Eglin, M. W. Laschke, M. Bischoff, R. G. Richards, T. F. Moriarty, Journal of Microbiological Methods, 2013, 92(1), 90-98