We enable nucleic acid labeling bioconjugation
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NHS-C3-Azide

Bifunctional Linker

Currency:  
  • Size
  • Catalog No.
  • Price
  • 5.0 mg
  • BCL-014-5

  • € 40,00
  • 10 mg
  • BCL-014-10

  • € 65,00
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  • This hetero-bifunctional reagent allows to crosslink alkyne (bio-)molecules to compounds bearing primary amines. The NHS ester group will react covalently with primary amines while the azide can undergo click reaction in catalyzed conditions with terminal alkynes. This linker is often used to introduce azide moieties into amino-oligonucleotides after solid phase synthesis.

    LITERATURE

    W. Hou, Y. Li, W. Kang, X. Wang, X. Wu, S. Wang, F. Liu, Scientific Reports, 2019, 9, 1307

    A.E. Kuznetsov, N. V. Komarova, E. V. Kuznetsov, M. S. Andrianova, V. P. Grudtsov, E. N. Rybachek, K. V. Puchnin, D. V. Ryazantsev, A. N. Saurov, Biosensors and Bioelectronics,
    2019, 129, 29-35

    P. Kumar, F. M. Kuhlmann, S. Chakroborty, A. L. Bourgeois, J. Foulke-Abel, B. Tumala, T. J. Vickers, D. A. Sack, B. DeNearing, C. D. Harro, W. S. Wright, J. C. Gildersleeve, M. A. Ciorba, S. Santhanam, C. K. Porter, R. L. Gutierrez, M. G. Prouty, M .S. Riddle, A. Polino, A. Sheikh, M. Donowitz, J. M. Fleckenstein, The Journal of clinical investigation, 2018, 128(8), 3298-3311

    M. Andrianova, N. Komarova, V. Grudtsov, E. Kuznetsov, Sensores, 2018, 18, 49

    A. Kuznetsov, N. Komarova, M. Andrianova, V. Grudtsov, E. Kuznetsov, Microchimica Acta, 2018, 185(1), 3

    M. Taskova, L. Miotke, M. Kubit, J. Bell, H. P. Ji, K. Astakhova, Analytical Chemistry, 2017, 89(8), 4363–4366

    J. Bu, A. L. Pilo, S. A. McLuckey, International Journal of Mass Spectrometry, 2015, 309, 118-123

    I. Potapova, D. Eglin, M. W. Laschke, M. Bischoff, R. G. Richards, T. F. Moriarty, Journal of Microbiological Methods, 2013, 92(1), 90-98

    • Molecular Formula

      C8H10N4O4

    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C, dry, inert gas

    • Molecular Weight

      226.19 g/mol

    • Purity

      ≥ 95% (H NMR)

    • Physical State

      Colorless crystalline solid

    • CAS Number

      943858-70-6

    • Additional name

      gamma-Azidobutyric acid oxysuccinimide ester; γ-Azidobutyric acid NHS; 2,5-dioxopyrrolidin-1-yl 4-azidobutanoate

    • Solubility

      DMSO, DMF, DCM

    • Preparation/Handling

      For a 10 mM solution add 442 μL to 1mg.