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NHS-C3-Azide
Bifunctional Linker

- Size
- Catalog No.
- Price
- 5.0 mg
BCL-014-5
- € 40,00
- 10 mg
BCL-014-10
- € 65,00
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This hetero-bifunctional reagent allows to crosslink alkyne (bio-)molecules to compounds bearing primary amines. The NHS ester group will react covalently with primary amines while the azide can undergo click reaction in catalyzed conditions with terminal alkynes. This linker is often used to introduce azide moieties into amino-oligonucleotides after solid phase synthesis.
LITERATURE
W. Hou, Y. Li, W. Kang, X. Wang, X. Wu, S. Wang, F. Liu, Scientific Reports, 2019, 9, 1307
A.E. Kuznetsov, N. V. Komarova, E. V. Kuznetsov, M. S. Andrianova, V. P. Grudtsov, E. N. Rybachek, K. V. Puchnin, D. V. Ryazantsev, A. N. Saurov, Biosensors and Bioelectronics,
2019, 129, 29-35P. Kumar, F. M. Kuhlmann, S. Chakroborty, A. L. Bourgeois, J. Foulke-Abel, B. Tumala, T. J. Vickers, D. A. Sack, B. DeNearing, C. D. Harro, W. S. Wright, J. C. Gildersleeve, M. A. Ciorba, S. Santhanam, C. K. Porter, R. L. Gutierrez, M. G. Prouty, M .S. Riddle, A. Polino, A. Sheikh, M. Donowitz, J. M. Fleckenstein, The Journal of clinical investigation, 2018, 128(8), 3298-3311
M. Andrianova, N. Komarova, V. Grudtsov, E. Kuznetsov, Sensores, 2018, 18, 49
A. Kuznetsov, N. Komarova, M. Andrianova, V. Grudtsov, E. Kuznetsov, Microchimica Acta, 2018, 185(1), 3
M. Taskova, L. Miotke, M. Kubit, J. Bell, H. P. Ji, K. Astakhova, Analytical Chemistry, 2017, 89(8), 4363–4366
J. Bu, A. L. Pilo, S. A. McLuckey, International Journal of Mass Spectrometry, 2015, 309, 118-123
I. Potapova, D. Eglin, M. W. Laschke, M. Bischoff, R. G. Richards, T. F. Moriarty, Journal of Microbiological Methods, 2013, 92(1), 90-98
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Molecular Formula
C8H10N4O4
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C, dry, inert gas
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Molecular Weight
226.19 g/mol
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Purity
≥ 95% (NMR)
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Physical State
White to off-white solid
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CAS Number
943858-70-6
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Additional name
gamma-Azidobutyric acid oxysuccinimide ester; Îł-Azidobutyric acid NHS; 2,5-dioxopyrrolidin-1-yl 4-azidobutanoate
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Solubility
DMSO, DMF, DCM
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Preparation/Handling
For a 10 mM solution add 442 ÎĽL to 1mg.
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Molecular Formula