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3′-(O-Propargyl)-ATP
Triphosphate for modifying of 3'END RNA
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3′-(O-Propargyl)-ATP can be incorporated in RNA at the 3’end using poly(A) Polymerase. The added alkyne can now be modified by Click Chemistry by reactions with azides. This is highly beneficial, as labeling of mRNA with this approach is modular and not limited to enzymatic compatibility of bulky pre-labeled nucleotides. Moreover, only a very limited number of such pre-modified nucleotides, mainly dye-labeled ones, are commercially available.
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Molecular Formula
C13H18N5O13P3 (free acid)
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C, dark, dry
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Molecular Weight
545.23 g/mol (free acid)
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Purity
≥ 95% (HPLC)
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Physical State
colorless to white solid
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CAS Number
n.a.
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Absorption (max)
λmax = 259 nm
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Ɛ (max)
15.300 cm-1M-1
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Salt Form
Triethylammonium salt
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Molecular Formula