We enable nucleic acid labeling bioconjugation
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5-Ethynyl-UTP

Modified Triphosphate for chemo-enzymatic labeling of long oligonucleotides

Currency:  
  • Size
  • Catalog No.
  • Price
  • 0.5 µmol
  • BCT-07-S

  • € 150,00
  • 2.5 µmol
  • BCT-07-M

  • € 580,00
  • 5.0 µmol
  • BCT-07-L

  • € 750,00
Clear
  • Our 5′-Ethynyl-UTP can be incorporated into RNA using standard nucleotide mixtures and T7 RNA polymerase guided in-vitro transcription. Ending up with a partially modified RNA (we recommend to replace the natural base by only 1-10% with the modified one), it is ready for labeling with our marker azides (e.g. fluorescent dyes for tracking and imaging or cross-linking to other biomolecules) by click chemistry.

    LITERATURE

    Presolski et al., Current Protocols of Chemical Biology, 2011, 3:153

    Hong et al., Angew. Chem. Int. Ed., 2011, 48:9879

    S.Croce, S. Serdjukow, T. Carell, T. Frischmuth, ChemBioChem, 2020, 21, 1-7

    • Molecular Formula

      C11H15N2O15P3

    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C

    • Molecular Weight

      507.97 g/mol

    • Purity

      ≥ 95% (HPLC)

    • Physical State

      100 mM clear aquaeous solution; colorless to slightly yellow

    • CAS Number

      n.a.

    • Absorption (max)

      λmax = 288 nm

    • Ɛ (max)

      12,000 cm-1M-1

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