We enable nucleic acid labeling bioconjugation
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ARCA (Anti-Reverse Cap Analog)

Cap Analog

  • Size
  • Catalog No.
  • Price
  • 1 µmol
  • BCT-24-S

  • € 95,00
  • 5 µmol
  • BCT-24-L

  • € 410,00
  • ARCA (Anti-Reverse Cap Analog) modified mRNA exhibits a longer half-life and the translation efficiency is increased by using this cap analog used during in vitro transcription for the generation of capped transcripts.


    Novel “anti-reverse” cap analogs with superior translational properties, J. Jemielity et al., 2003, RNA, Vol. 9, p. 1108-1122.


    Synthesis and Application of a Chain-Terminating Dinucleotide mRNA Cap Analog, Z. Peng et al., 2002, Org. Lett., Vol. 4(2), p. 161-164.


    5-Ethynyluridine: A Bio-orthogonal Uridine Variant for mRNA-Based Therapies and Vaccines, S. Maassen et al., 2023ChemBioChem, Vol. 24(5), e202200658.


    Chemoenzymatic Preparation of Functional Click-Labeled Messenger RNA, S. Croce et al., 2020, ChemBioChem, Vol. 21(11), p. 1641-1646.


    • Molecular Formula


    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C

    • Molecular Weight

      816.46 g/mol

    • Purity

      ≥ 98% (HPLC)

    • Physical State

      100 mM clear aquaeous solution; colorless

    • CAS Number

      400806-46-4 (acid),
      400806-60-2 (sodium salt)

    • Absorption (max)

      λmax = 255 nm

    • Ɛ (max)

      22,600 cm-1M-1

    • Additional name

      m27,3′-OGP3G; m27,3′-OG(5′)ppp(5′)G; P1-(5′-(3′-O-methyl)-7-methyl-guanosyl) P3-(5′-(guanosyl))triphosphate, Sodium salt