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Azido-PEG4-Trimannose

Clickable trimannose identifier for target delivery

Size Catalog No. Price
5 mg BCFA-244-5  400,00
10 mg BCFA-244-10  680,00
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  • Azido-PEG4-Trimannose enables the possibility to click label an Alkyne or DBCO modified target with an 3,6-di-O-(α-D-mannopyranosyl)-α-D-mannopyranoside moity by CuAAC. The Trimannose structure is recognized by the mannose receptor and leads to transportation into the cell by internalized receptor mediated endocytosis. Therefore this molecule offers a possibility for target delivery of biomolecules to the cell.

     

    LITERATURE

    Synthesis and affinities of C3-symmetric thioglycoside-containing trimannosides, J. Bi et al., 2015, Carbohydrate Research, Vol. 412, p. 56-65.

    https://doi.org/10.1016/j.carres.2015.05.001

    A structure of the complex between concanavalin A and methyl-3, 6-di-O-(α-D-mannopyranosyl)-α-D-mannopyranoside reveals two binding modes, R. Loris et al., 1996, Journal of Biological Chemistry, Vol. 271(48), p. 30614-30618.

    https://doi.org/10.1074/jbc.271.48.30614

    • Molecular Formula

      C35H56N4O21

    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C, dark, inert gas

    • Molecular Weight

      868.83 g/mol

    • Purity

      ≥ 95% (HPLC)

    • Physical State

      white amorphous solid

    • CAS Number

      n.a.

    • Additional name

      Azido-PEG4-carbonylaminophenyl 3,6-di-O-(α-D-mannopyranosyl)-α-D-mannopyranoside

    • Solubility

      H2O, DMSO

    • Preparation/Handling

      For a 10 mM solution add 575 μL to 5 mg.
      For a 10 mM solution add 1151 μL to 10 mg.

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