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Tri-GalNAc-DBCO

Copper-free clickable Tri-GalNAc identifier for target delivery

Size Catalog No. Price
5 mg BCFA-245-5 € 530,00
10 mg BCFA-245-10 € 950,00
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  • Tri-GalNAc-DBCO enables the possibility to click label an azide modified target with an Tri-GalNAc by strain-promoted Alkyne-Azide cycloaddition (SPAAC). The Tri-GalNAc structure is recognized by the desialic acid glycoprotein receptor (ASGPR) and can be therefore used to target delivery of biomolecules as siRNA to liver tissue.

     

    LITERATURE

    Site-Selective LYTACs for Targeted Protein Degradation, D. Trauner et al., 2021, Synfacts, Vol. 17(07), 0818.

    https://doi.org/10.1055/s-0040-1719647

    LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation, G. Ahn et al., 2021, Nature Chemical Biology, Vol. 17(9), p. 937-946.

    https://doi.org/10.1038/s41589-021-00770-1

    Targeting the Epidermal Growth Factor Receptor with Molecular Degraders: State-of-the-Art and Future Opportunities, P. Maity et al., 2023, Journal of Medicinal Chemistry, Vol. 66(5), p. 3135-3172.

    https://doi.org/10.1021/acs.jmedchem.2c01242

    • Molecular Formula

      C82H127N11O29

    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      20 °C, dark

    • Molecular Weight

      1730.94 g/mol

    • Purity

      ≥ 95% (HPLC)

    • Physical State

      white to off-white solid

    • CAS Number

      n.a.

    • Solubility

      H2O, DMSO

    • Preparation/Handling

      For a 10 mM solution add 289 μL to 5 mg.
      For a 10 mM solution add 578 μL to 10 mg.

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