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Biotinylation reagent for labeling by CuAAC

Size Catalog No. Price
5 mg BCFA-234-5  70,00
10 mg BCFA-234-10  110,00
  • Biotin-PEG4-Azide is a biotin probe that enables the possibility for copper-catalyzed Azide-Alkyne Chemistry (CuAAC) to biotin label alkyne or DBCO modified targets. Once the biotin is attached to a biomolecule, fluorescence microscopy detection can be carried out using the well-known signal enhancement strategy of incubation with a fluorescent streptavidin-conjugate.

    The introduction for the hydrophilic PEG4-moity (19 atoms) reduces aggregation and precipitation during the labeling reaction due to an increase in hydrophilicity and also enhances the detection efficiency of the biotin due to reducing sterically hindrance.



    Discovery of an NAD+ analogue with enhanced specificity for PARP1, X. N. Zhang et al., 2022, Chemical Science, Vol. 13(7), p. 1982-1991.


    Epitopes displayed in a cyclic peptide scaffold bind SARS‐CoV‐2 antibodies, C. Eriksson et al., 2023, ChemBioChem, Vol. 24(15), e202300103.


    Functionalized scout fragments for site-specific covalent ligand discovery and optimization, V. M. Crowley et al., 2021, ACS Central Science, Vol. 7(4), p. 613-623.


    • Molecular Formula


    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C, dark

    • Molecular Weight

      488.6 g/mol

    • Purity

      ≥ 95% (HPLC)

    • Physical State

      white to light yellow solid to lump

    • CAS Number


    • Solubility

      DMSO, DMF

    • Preparation/Handling

      For a 10 mM solution add 1023 μL to 5 mg.
      For a 10 mM solution add 2047 μL to 10 mg.