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C8-Alkyne-dC-CE Phosphoramidite

Clickable phosphoramidite for Oligo synthesis

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  • Size
  • Catalog No.
  • Price
  • 250 mg
  • BCA-07-250

  • 320 €
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  • This C8-Alkyne-dC-CE Phosphoramidite, containing a C8-Spacer, is used under standard conditions for solid phase synthesis of oligonucleotides. It has shown to be incorporated into DNA oligomers with excellent coupling efficiency.

    LITERATURE

    Postsynthetic DNA Modification through the Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction, P. M. E. Gramlich et al., 2008, Angew. Chemie Int. Ed., Vol. 47, p. 8350–8358.

    https://doi.org/10.1002/anie.200802077

    Click–Click–Click: Single to Triple Modification of DNA, P. M. E. Gramlich et al., 2008, Angew. Chemie Int. Ed., Vol. 47, p. 3442-3444.

    https://doi.org/10.1002/anie.200705664

    Generation and Characterization of a DNA-GCN4 Oligonucleotide-Peptide Conjugate: The Impact DNA/Protein Interactions on the Sensitization of DNA, P. Wityk et al., 2020, Molecules, Vol. 25(16), p. 3630.

    https://doi.org/10.3390/molecules25163630

    • Molecular Formula

      C54H60N5O8P

    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C dry, inert gas

    • Molecular Weight

      938.06 g/mol

    • Purity

      ≥ 95% (31P NMR)

    • Physical State

      white to off-white solid

    • CAS Number

      1021300-97-9

    • Additional name

      C8-Alkyne-dC-phosphoramidite, 4-N-Benzoyl-5-(octa-1,7-diynyl)-3´-O-[(2-cyanoethoxy)(diisopropylamino)-phosphono)]-5´-O-(4,4´-dimethoxytrityl)-2’-deoxycytidine

    • Preparation/Handling

      This phosphoramidite is used under standard conditions for solid phase synthesis of oligonucleotides.

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