Product Application for...
Product Emission color
Product Enatiomeric structure
Product Kits for..
Product Label Position
Product Linker type
Product Modification Type
Product Nucleoside
Product Nucleosites
Product Protection Type
Product Sort by
Product Sugar core
C8-Alkyne-dC-CE Phosphoramidite
Clickable phosphoramidite for Oligo synthesis
-
This C8-Alkyne-dC-CE Phosphoramidite, containing a C8-Spacer, is used under standard conditions for solid phase synthesis of oligonucleotides. It has shown to be incorporated into DNA oligomers with excellent coupling efficiency.
LITERATURE
Postsynthetic DNA Modification through the Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction, P. M. E. Gramlich et al., 2008, Angew. Chemie Int. Ed., Vol. 47, p. 8350–8358.
https://doi.org/10.1002/anie.200802077
Click–Click–Click: Single to Triple Modification of DNA, P. M. E. Gramlich et al., 2008, Angew. Chemie Int. Ed., Vol. 47, p. 3442-3444.
https://doi.org/10.1002/anie.200705664
Generation and Characterization of a DNA-GCN4 Oligonucleotide-Peptide Conjugate: The Impact DNA/Protein Interactions on the Sensitization of DNA, P. Wityk et al., 2020, Molecules, Vol. 25(16), p. 3630.
-
-
Molecular Formula
C54H60N5O8P
-
Shelf Life
12 months unopened after receipt
-
Storage Conditions
-20 °C dry, inert gas
-
Molecular Weight
938.06 g/mol
-
Purity
≥ 95% (31P NMR)
-
Physical State
white to off-white solid
-
CAS Number
1021300-97-9
-
Additional name
C8-Alkyne-dC-phosphoramidite, 4-N-Benzoyl-5-(octa-1,7-diynyl)-3´-O-[(2-cyanoethoxy)(diisopropylamino)-phosphono)]-5´-O-(4,4´-dimethoxytrityl)-2’-deoxycytidine
-
Preparation/Handling
This phosphoramidite is used under standard conditions for solid phase synthesis of oligonucleotides.
-
Molecular Formula