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C8-Alkyne-dU-CE Phosphoramidite

Clickable phosphoramidite for Oligo synthesis

  • Size
  • Catalog No.
  • Price
  • 250 mg
  • BCA-03-250

  • € 210,00
  • 1 g
  • BCA-03-1g

  • € 630,00
  • 5 g
  • BCA-03-5g

  • € 2.500,00
  • This C8-Alkyne-dU-CE Phosphoramidite, containing a C8-Spacer, is used under standard conditions for solid phase synthesis of oligonucleotides. It has shown to be incorporated into DNA oligomers with excellent coupling efficiency.


    Nucleosides And Oligonucleotides With Diynyl Side Chains: The Huisgen-Sharpless Cycloaddition “Click Reaction” Performed On Dna And Their Constituents, F. Seela et al., 2007, Nucleosides, Nucleotides & Nucleic Acids, Vol. 26, p. 597–601.


    DNA-Photographie: eine ultraempfindliche Methode zur Detektion von DNA mithilfe photographischer Techniken, D. M. Hammond et al., 2007, Angew. Chem., Vol. 119, p. 4262–4265.


    Transfer Printing of DNA by “Click” Chemistry, D. I. Rozkiewicz et al., 2007, ChemBioChem, Vol. 8, p. 1997–2002.


    DNA Containing Side Chains with Terminal Triple Bonds: Base-Pair Stability and Functionalization of Alkynylated Pyrimidines and 7-Deazapurines, F. Seela et al., 2006, Chemistry & Biodiversity, Vol. 3, p. 509–514.


    Click Chemistry as a Reliable Method for the High-Density Postsynthetic Functionalization of Alkyne-Modified DNA, J. Gierlich et al., 2006, Org. Lett., Vol. 8, p. 3639–3642.


    A click chemistry approach to developing molecularly targeted DNA scissors, T. Lauria et al., 2020, Chemistry – A European Journal, Vol. 26(70), p. 16782-16792.


    Supersensitive Multifluorophore RNA‐FISH for Early Virus Detection and Flow‐FISH by Using Click Chemistry, N. Raddaoui et al., 2020, ChemBioChem, Vol. 21(15), p. 2214-2218.


    Selective targeting and degradation of doxorubicin-loaded folate-functionalized DNA nanocages, S. Raniolo et al., 2018, Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 14(4), p. 1181-1190.


    • Molecular Formula


    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C dry, inert gas

    • Molecular Weight

      834.94 g/mol

    • Purity

      ≥ 95% (HPLC & 31P-NMR)

    • Physical State

      white to off-white / light yellow solid

    • CAS Number


    • Additional name

      C8-Alkyne-dU-phosphoramidite, 5-(Octa-1,7-diynyl)-3`-O-[(2-cyanoethoxy)(diisopropylamino)-phosphono)]-5`-O- (4,4`-dimethoxytrityl)-2`-deoxyuridine

    • Preparation/Handling

      C8-Alkyne-dU-CE Phosphoramidite is used under standard conditions for solid phase synthesis of oligonucleotides.