Clean Cap
Cap structure for increasing IVT yield of RNA
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Clean Cap modified mRNA exhibits a longer half-life and the translation efficiency is increased by using this cap analog during in vitro transcription for the generation of capped transcripts.
LITERATURE
Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope, T. Jiang et al., 2020, Nature Communications, Vol. 11, 1979.
https://doi.org/10.1038/s41467-020-15892-8
Cap 1 messenger RNA synthesis with co‐transcriptional cleancap® analog by in vitro transcription, J. M. Henderson et al., 2021, Current Protocols, Vol. 1(2), e39.
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- Molecular Formula
C32H43N15O24P4 (free acid)
- Shelf Life
12 months unopened after receipt
- Storage Conditions
-20 °C, dark, dry
- Molecular Weight
1145.60 g/mol (free acid)
- Purity
≥ 95% (HPLC)
- Physical State
colorless solution (100 mM)
- CAS Number
n.a.
- Absorption (max)
λmax = 255 nm
- Ɛ (max)
30.539 cm-1M-1
- Additional name
m7G(5′)ppp(5′)(2’OMeA)pG
- Molecular Formula