We enable nucleic acid labeling bioconjugation
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Pseudouridine Triphosphate (Pseudo-UTP)

Stabilizing Triphosphate for RNA

  • Size
  • Catalog No.
  • Price
  • 1 µmol
  • BCT-23-S

  • € 65,00
  • 5 µmol
  • BCT-23-L

  • € 300,00
  • Pseudouridine Triphosphate (Pseudo-UTP) modified mRNA exhibits longer half-life, a better translation efficiency and its immunological properties are improved.


    Activation of Autoreactive B Cells by Endogenous TLR7 and TLR3 RNA Ligands, N. Green et al., 2012, J. Biol. Chem., Vol. 287(47), p. 39789-39799.


    Transient Focal Membrane Deformation Induced by Arginine-rich Peptides Leads to Their Direct Penetration into Cells, H. Hirose et al., 2012, Mol Ther., Vol. 20(5), p. 984-993.


    Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA, L. Warren et al., 2012, Sci Rep., Vol. 2, p. 657.


    Nucleoside modifications in RNA limit activation of 2′-5′-oligoadenylate synthetase and increase resistance to cleavage by RNase L, B. Anderson et al., 2011, Nucleic Acids Research, Vol. 39(21), p. 9329-9338.


    Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA, K. Karikó et al., 2011, Nucleic Acids Research, Vol. 39(21), p. e142.


    Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation, B. Anderson et al., 2010, Nucleic Acids Research, Vol. 38(17), p. 5884-5892.


    Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA, L. Warren et al., 2010, Cell Stem Cell, Vol. 7(5), p. 618-630.


    Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability, K. Karikó et al., 2008, Molecular Therapy, Vol. 16(11), p. 1833-1840.


    Norovirus Proteinase-Polymerase and Polymerase Are Both Active Forms of RNA-Dependent RNA Polymerase, G. Belliot et al., 2005, Journal of Virology, Vol. 79(4), p. 2393-2403.


    Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA, K. Karikó et al., 2005, Immunity, Vol. 23(2), p. 165-175.


    Pseudouridine in RNA: What, Where, How, and Why, M. Charette et al., 2000, IUBMB Life, Vol. 49(5), p. 341-351.


    Comparative Utilization of Pseudouridine Triphosphate and Uridine Triphosphate by Ribonucleic Acid Polymerase, I. Goldberg et al., 1963, J. Biol. Chem., Vol. 238(5), p. 1793-1800.


    5-Ethynyluridine: A Bio-orthogonal Uridine Variant for mRNA-Based Therapies and Vaccines, S. Maassen et al., 2023, ChemBioChem, Vol. 24(5), e202200658.


    Incorporation of Synthetic mRNA in Injectable Chitosan-Alginate Hybrid Hydrogels for Local and Sustained Expression of Exogenous Proteins in Cells, H. Steinle et al., 2018, Int. J. Mol. Sci., Vol. 19(5), p. 1313.


    Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm, W. Wang et al., 2022, Acta Pharmaceutica Sinica B, Vol. 12(6), p. 2950-2962.


    • Molecular Formula


    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20 °C

    • Molecular Weight

      484.14 g/mol

    • Purity

      ≥ 95% (HPLC)

    • Physical State

      100 mM clear aquaeous solution; colorless

    • CAS Number

      28022-82-4 (sodium salt)

      1175-34-4 (free acid)

    • Additional name

      Pseudo-UTP, 5-Ribosyl Uracil

    • Absorption (max)

      λmax = 262 nm

    • Ɛ (max)

      7,500 cm-1M-1