DBCO-C6-Alkyne
Bifunctional linker
| Size | Catalog No. | Price |
|---|---|---|
| 5 mg | BCL-035-5 | € 110,00 |
| 10 mg | BCL-035-10 | € 180,00 |
Chemical Properties
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Molecular Formula
C24H22N2O2
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C, dark
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Molecular Weight
370.45 g/mol
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Purity
≥ 95% (HPLC)
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Physical State
white to off-white solid
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CAS Number
n.a.
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Additional name
N-(propargylamidoadipoyl)-dibenzoazacyclooctyne
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Solubility
DMSO, DMF, DCM, THF, Chloroform
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Preparation/Handling
For a 10 mM solution add 1350 μL to 5 mg.
For a 10 mM solution add 2699 μL to 10 mg.
Product Information
The heterobifunctional linker DBCO-C6-Alkyne contains an Alkyne and a DBCO moiety which enable the possibility to perform two sequential click reactions in an orthogonal way. Therefore this linker offers a great potential to cross link to azide containg biomolecules by just using high efficient Click Chemistry. There is also the possibility to selectively click the alkyne before the DBCO [1]. Therefore this linker offers great potential for the synthesis of Antibody-drug-conjugates (ADC).
LITERATURE
[1] Transient protection of strained alkynes from click reaction via complexation with copper, S. Yoshida et al., 2014, Journal of the American Chemical Society, Vol. 136(39), p. 13590-13593.