DBCO-C6-NHS ester
Bifunctional linker
| Size | Catalog No. | Price |
|---|---|---|
| 5 mg | BCL-037-5 | € 60,00 |
| 10 mg | BCL-037-10 | € 90,00 |
| 50 mg | BCL-037-50 | € 240,00 |
Chemical Properties
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Molecular Formula
C25H22N2O5
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C, dark
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Molecular Weight
430.5 g/mol
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Purity
≥ 95% (HPLC)
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Physical State
white to slightly grey crystalline solid
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CAS Number
1384870-47-6
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Additional name
1-{[6-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-6-oxohexanoyl]oxy}-2,5-pyrrolidinedione
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Solubility
DCM, THF, Acetonitrile, DMF, DMSO
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Preparation/Handling
For a 10 mM solution add 1161 μL to 5 mg.
For a 10 mM solution add 2323 μL to 10 mg.
Product Information
The bifunctional linker DBCO-C6-NHS ester contains a DBCO and a NHS ester moiety which allows to crosslink azide containing compounds with compounds bearing primary amines without the need of a catalyst. The C6 spacer arms enables solubility of the linker in commonly used organic solvents as DCM, THF, ethyl acetate and many more.
The product is not recommended for reactions which has to be performed in aqueous solution due to its poor water solubility. For this purpose the usage of DBCO-PEG4-NHS ester (BCL-038) is recommended.
LITERATURE
ICAM-1-targeted and antibacterial peptide modified polymeric nanoparticles for specific combating sepsis, L. Pan et al., 2022, Materials & Design, Vol. 222, 111007.
https://doi.org/10.1016/j.matdes.2022.111007
Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics, J. Wiener et al., 2020, Scientific Reports, Vol. 10(1), 1457.