DBCO-PEG4-DBCO
Homobifunctional linker
| Size | Catalog No. | Price |
|---|---|---|
| 5 mg | BCL-039-5 | € 100,00 |
| 10 mg | BCL-039-10 | € 150,00 |
Chemical Properties
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Molecular Formula
C48H50N4O8
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C, dark, dry
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Molecular Weight
811 g/mol
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Purity
≥ 98% (HPLC)
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Physical State
yellow gel
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CAS Number
2182601-68-7
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Solubility
DMSO, MeOH, DMF
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Preparation/Handling
For a 10 mM solution add 123 μL per 1 mg.
Product Information
The homo bifunctional linker DBCO-PEG4-DBCO contains two DBCO moieties which enable reaction with two azides. This linker is well suited for cross linking when used in excess [1,2] but enables other interesting possibilities as circularization of biomolecules containing two azides. The hydrophilic PEG4 spacer increase water solubility needed for reaction with biomolecules in aqueous media.
LITERATURE
[1] Generation of therapeutic protein variants with the human serum albumin binding capacity via site-specific fatty acid conjugation, J. Cho et al., 2017, Scientific Reports, Vol. 7(1), 18041.
https://doi.org/10.1038/s41598-017-18029-y
[2] An expanded genetic code facilitates antibody chemical conjugation involving the lambda light chain, A. Kato et al., 2021, Biochemical and Biophysical Research Communications, Vol. 546, p. 35-39.
https://doi.org/10.1016/j.bbrc.2021.02.005
Characterization and scaled-up production of azido-functionalized silk fiber produced by transgenic silkworms with an expanded genetic code, H. Teramoto et al., 2019, International Journal of Molecular Sciences, Vol. 20(3), 616.