DBCO-PEG4-NHS ester
Bifunctional linker
| Size | Catalog No. | Price |
|---|---|---|
| 5 mg | BCL-038-5 | € 90,00 |
| 10 mg | BCL-038-10 | € 140,00 |
| 50 mg | BCL-038-50 | € 480,00 |
Chemical Properties
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Molecular Formula
C34H39N3O10
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C, dark, dry, inert gas
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Molecular Weight
649.7 g/mol
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Purity
≥ 98% (HPLC)
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Physical State
light yellow gel
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CAS Number
1427004-19-0
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Additional name
DBCO-PEG4-succinimidyl Ester, 2,5-Dioxo-1-pyrrolidinyl 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo-4,7,10,13-tetraoxa-16-azaeicosanoate
Dibenzocyclooctyne-PEG4-succinimidyl Ester -
Solubility
DMSO, DCM, DMF
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Preparation/Handling
For a 10 mM solution add 154 μL per 1 mg.
Product Information
The bifunctional linker DBCO-PEG4-NHS ester contains a DBCO and a NHS ester moiety which allows to crosslink azide containing compounds with compounds bearing primary amines without the need of a catalyst. The introduction of the hydrophilic PEG4 spacer reduces aggregation and precipitation during the labeling reaction and also minimizes steric hindrance between the conjugate.
LITERATURE
Equipping natural killer cells with cetuximab through metabolic glycoengineering and bioorthogonal reaction for targeted treatment of KRAS mutant colorectal cancer, X. Wang et al., 2021, ACS Chemical Biology, Vol. 16(4), p. 724-730.
https://doi.org/10.1021/acschembio.1c00022
Enzyme‐Based Synthetic Protein Nanoparticles as Colloidal Antioxidants, A. Mauser et al., 2023, Advanced Therapeutics, 2300007.
https://doi.org/10.1002/adtp.202300007
Construction of artificial cilia from microtubules and kinesins through a well-designed bottom-up approach, R. Sasaki et al., 2018, Nanoscale, Vol. 10(14), p. 6323-6332.