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3′-(O-Propargyl)-GTP
Triphosphate for cap modifying of 5'END RNA
| Size | Catalog No. | Price |
|---|---|---|
| 1 µmol | BCT-32-S | € 800,00 |
Chemical Properties
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Molecular Formula
C13H18N5O14P3 (free acid)
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C, dark, dry
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Molecular Weight
561.23 g/mol (free acid)
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Purity
≥ 95% (HPLC)
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Physical State
colorless to white solid
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CAS Number
1610778-63-6
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Absorption (max)
λmax = 252 nm
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Ɛ (max)
13.700 cm-1M-1
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Salt Form
Triethylammonium salt
Product Information
3′-(O-Propargyl)-GTP can be incorporated in RNA at the 3’end using poly(A) Polymerase. But for adding an alkyne to the 3′-end 3′-(O-Propargyl)-ATP (BCT-31) is superior. We developed a different approach in which 3′-(O-Propargyl)-GTP is added to mRNA to the 5’end with an capping enzyme and afterwards methylated. As a result a cap-like structure is created which provides all the advantages of a cap structure together with the possibility to perform click reactions at the incorporated alkyne.