Azido-PEG4-Trimannose
Clickable trimannose identifier for target delivery
| Size | Catalog No. | Price |
|---|---|---|
| 5 mg | BCFA-244-5 | € 400,00 |
| 10 mg | BCFA-244-10 | € 680,00 |
Chemical Properties
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Molecular Formula
C35H56N4O21
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C, dark, inert gas
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Molecular Weight
868.83 g/mol
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Purity
≥ 98% (HPLC)
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Physical State
white amorphous solid
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CAS Number
n.a.
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Additional name
Azido-PEG4-carbonylaminophenyl 3,6-di-O-(α-D-mannopyranosyl)-α-D-mannopyranoside
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Solubility
H2O, DMSO
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Preparation/Handling
For a 10 mM solution add 575 μL to 5 mg.
For a 10 mM solution add 1151 μL to 10 mg.
Product Information
Azido-PEG4-Trimannose enables the possibility to click label an Alkyne or DBCO modified target with an 3,6-di-O-(α-D-mannopyranosyl)-α-D-mannopyranoside moity by CuAAC. The Trimannose structure is recognized by the mannose receptor and leads to transportation into the cell by internalized receptor mediated endocytosis. Therefore this molecule offers a possibility for target delivery of biomolecules to the cell.
LITERATURE
Synthesis and affinities of C3-symmetric thioglycoside-containing trimannosides, J. Bi et al., 2015, Carbohydrate Research, Vol. 412, p. 56-65.
https://doi.org/10.1016/j.carres.2015.05.001
A structure of the complex between concanavalin A and methyl-3, 6-di-O-(α-D-mannopyranosyl)-α-D-mannopyranoside reveals two binding modes, R. Loris et al., 1996, Journal of Biological Chemistry, Vol. 271(48), p. 30614-30618.