C8-Alkyne-dC-CE Phosphoramidite
Clickable phosphoramidite for Oligo synthesis
| Size | Catalog No. | Price |
|---|---|---|
| 250 mg | BCA-07-250 | € 260,00 |
Chemical Properties
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Molecular Formula
C54H60N5O8P
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Shelf Life
12 months unopened after receipt
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Storage Conditions
-20 °C dry, inert gas
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Molecular Weight
938.06 g/mol
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Purity
≥ 95% (31P NMR)
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Physical State
white to off-white solid
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CAS Number
1021300-97-9
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Additional name
C8-Alkyne-dC-phosphoramidite, 4-N-Benzoyl-5-(octa-1,7-diynyl)-3´-O-[(2-cyanoethoxy)(diisopropylamino)-phosphono)]-5´-O-(4,4´-dimethoxytrityl)-2’-deoxycytidine
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Preparation/Handling
This phosphoramidite is used under standard conditions for solid phase synthesis of oligonucleotides.
Product Information
This C8-Alkyne-dC-CE Phosphoramidite, containing a C8-Spacer, is used under standard conditions for solid phase synthesis of oligonucleotides. It has shown to be incorporated into DNA oligomers with excellent coupling efficiency.
LITERATURE
Postsynthetic DNA Modification through the Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction, P. M. E. Gramlich et al., 2008, Angew. Chemie Int. Ed., Vol. 47, p. 8350–8358.
https://doi.org/10.1002/anie.200802077
Click–Click–Click: Single to Triple Modification of DNA, P. M. E. Gramlich et al., 2008, Angew. Chemie Int. Ed., Vol. 47, p. 3442-3444.
https://doi.org/10.1002/anie.200705664
Generation and Characterization of a DNA-GCN4 Oligonucleotide-Peptide Conjugate: The Impact DNA/Protein Interactions on the Sensitization of DNA, P. Wityk et al., 2020, Molecules, Vol. 25(16), p. 3630.