We enable nucleic acid labeling bioconjugation
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TIPS-5-Ethynyl-dU-CEP

Clickable Oligo Synthesis Building Block

Currency:  
  • Size
  • Catalog No.
  • Price
  • 100 mg
  • BCA-25-100

  • € 250,00
  • 250 mg
  • BCA-25-250

  • € 580,00
  • 1.0 g
  • BCA-25-1g

  • € 1.800,00
Clear
  • This new TIPS-EdU phosphoramidite replaces the EdU-CEP. With its protecting group the risk of side products is circumvented. The oligo will be deprotected after the synthesis leading to ethynyl modified oligonucleotides that are ready for click conjugations with various azide labels. Also this universal alkyne modifier that can be used under standard conditions for solid phase synthesis of oligonucleotides.

    LITERATURE

    “F. Seela, V. R. Sirivolu, Nucleosides, nucleotides {&} nucleic acids 2007, 26, 597–601.

    P. M. E. Gramlich, C. T. Wirges, A. Manetto, T. Carell, Angew. Chemie – Int. Ed. 2008, 47, 8350–8358.

    S. A. Ingale, H. Mei, P. Leonard, F. Seela, J. Org. Chem. 2013, 78, 11271–11282.

    P. Wu, A. K. Feldman, A. K. Nugent, C. J. Hawker, A. Scheel, B. Voit, J. Pyun, J. M. J. Fréchet, K. B. Sharpless, V. V. Fokin, Angew. Chemie – Int. Ed. 2004, 43, 3928–3932.

    C. W. Tornøe, C. Christensen, M. Meldal, J. Org. Chem. 2002, 67, 3057–3064.

    H. C. Kolb, M. G. Finn, K. B. Sharpless, Angew. Chemie – Int. Ed. 2001, 40, 2004–2021.

    M. Slater, M. Snauko, F. Svec, J. M. J. Fréchet, S. Hotha, S. Kashyap, Y. Sohma, Y. Kiso, T. L. Mindt, H. Struthers, et al., J. Am. Chem. Soc. 2005, 7, 1–6.”

    • Molecular Formula

      C50H67N4O8PSi

    • Shelf Life

      12 months unopened after receipt

    • Storage Conditions

      -20°C dry, inert gas

    • Molecular Weight

      911.16 g/mol

    • Purity

      ≥ 90% (LCMS and 31P NMR)

    • Physical State

      off-white colored fluffy solid

    • CAS Number

      n.a.

    • Additional name

      5-TIPS-EDU Amidite; TIPS-5-Ethynyl dU CEP; TIPS-5-Ethynyl dU Phosphoramidite

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