Tri-GalNAc-DBCO
Copper-free clickable Tri-GalNAc identifier for target delivery
| Size | Catalog No. | Price |
|---|---|---|
| 5 mg | BCFA-245-5 | € 580,00 |
| 10 mg | BCFA-245-10 | € 990,00 |
Chemical Properties
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Molecular Formula
C82H127N11O29
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Shelf Life
12 months unopened after receipt
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Storage Conditions
–20 °C, dark
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Molecular Weight
1730.94 g/mol
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Purity
≥ 98% (HPLC)
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Physical State
white to off-white solid
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CAS Number
n.a.
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Solubility
H2O, DMSO
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Preparation/Handling
For a 10 mM solution add 289 μL to 5 mg.
For a 10 mM solution add 578 μL to 10 mg.
Product Information
Tri-GalNAc-DBCO enables the possibility to click label an azide modified target with an Tri-GalNAc by strain-promoted Alkyne-Azide cycloaddition (SPAAC). The Tri-GalNAc structure is recognized by the desialic acid glycoprotein receptor (ASGPR) and can be therefore used to target delivery of biomolecules as siRNA to liver tissue.
LITERATURE
Site-Selective LYTACs for Targeted Protein Degradation, D. Trauner et al., 2021, Synfacts, Vol. 17(07), 0818.
https://doi.org/10.1055/s-0040-1719647
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation, G. Ahn et al., 2021, Nature Chemical Biology, Vol. 17(9), p. 937-946.
https://doi.org/10.1038/s41589-021-00770-1
Targeting the Epidermal Growth Factor Receptor with Molecular Degraders: State-of-the-Art and Future Opportunities, P. Maity et al., 2023, Journal of Medicinal Chemistry, Vol. 66(5), p. 3135-3172.