Integrated synthesis and post‑synthetic conjugation for research, diagnostics, and pharmaceutical development
Modern molecular biology, diagnostics, and pharmaceutical development increasingly rely on functionalized, targeted, and chemically defined oligonucleotides. Custom oligonucleotide synthesis and conjugation are central to our service offering. Synthesize your Oligo with metabion’s high‑precision combined with baseclick’s advanced conjugation and glyco‑engineering platform to get targeted and functionalized oligos in one step.
Custom Oligonucleotide Synthesis and Conjugation Services
From non functionalized Oligos to high modified, Target‑Ready Oligo
Integrated synthesis and post‑synthetic conjugation for research, diagnostics, and pharmaceutical development.
baseclick Oligo Capabilities and Technical Specifications
Sugar Ligands
- Tri-GalNAc
- Tri-Mannose Mannose-6-phosphate
- Lewis antigens
- LacNAc & sialic acid motifs
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Fluorophores
- Fluorescein Azide
- 5-TAMRA Azide
- 5-TAMRA-PEG3-Azide
- Texas Red
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Click Handles
- Alkyne / Azide
- DBCO
- NHS esters
- PEG linkers
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Other Functional Groups
- Biotin
- desthiobiotin Peptides
- Fatty acids
- Reporter tags
- Learn more
Biological Advantages
- Ligand‑modified oligonucleotides enable receptor‑mediated cellular uptake.
- Glyco‑conjugates show enhanced transfer in target tissues.
- Chemical stabilization improves serum resistance and reduces degradation, resulting in lower immunogenicity.
- Targeted delivery decreases off‑target exposure and required dosage.
Functional Advantages
- Conjugation allows precise incorporation of dyes, PEGs, lipids, or peptides.
- Click‑ready handles enable modular and site‑specific functionalization.
- Fluorescence labeled oligos enable high‑resolution imaging and quantification.
- Custom linkers permit controlled spacing, flexibility, and molecular orientation.
