Eurofins Genomics x baseclick cooperation
One Step DNA Template and mRNA synthesis: Get high-quality, ready-to-use mRNA designed exactly for your needs, from native mRNA to highly functionalised mRNA.
We offer specialized mRNAs designed for advanced applications. Our portfolio includes dye-labeled mRNAs [1] for precise tracking, as well as mRNAs conjugated via click with targeting agents for specific delivery. Furthermore, we offer innovative modifications beyond traditional methyl-pseudouridine. Notably, our 5’-ethynyl uridine modification extends mRNA expression, providing enhanced stability and performance [2].
high quality mRNA
attractive prices
support for success
up to 10 mg scales
Choices
When ordering custom mRNA you have a variety of options to tailor the product to your specific requirements. If you don’t see your preferred option listed, please reach out to us. We are more than happy to discuss a custom project with you.
| Choice | Description |
| Capping | Co-transcriptional (ARCA, Cap 1) |
| Capping efficiency | 80-95% (ARCA) 95-99% (Cap 1 analog) |
| Cap-type | Cap-0 (for standard cell-types) Cap-1 (for immune cells & in vivo applications) |
| 3‘ or 5‘ end Label | DBCO-AF647 (ex 647nm / em 670nm) DBCO-AF488 (ex 488nm / em 530nm) Biotin Desthiobiotin Tri-GalNAc Tri-Mannose Other labels available upon request |
| Internal Dye Label | Picolyl azide 647 (ex 647nm / em 670nm) Picolyl azide 488 (ex 488nm / em 530nm) Biotin Other labels available upon request |
| Poly(A)tail length | 20-150nt Segmented |
| Amount | 50 µg – 10 mg |
| Buffer | TRIS (pH 7.5) Sodium Citrate (pH 6.4)water Other buffer |
What You Get
Together, we provide researchers and developers with ready-to-use, customized mRNA molecules for therapeutic, diagnostic, or research applications.
Our Joint mRNA Service Includes:
- Plasmid DNA production (via Eurofins)
- High-yield IVT mRNA synthesis (via baseclick)
- 5′-Capping & poly-A tailing
- Internal base modifications (e.g., Pseudouridine, 5-EU)
- Site-specific click conjugation (fluorophores, ligands, biotin, etc.)
- Quality control and data documentation
- Support for downstream LNP encapsulation or in vivo delivery
How we proceed with your order
We make it simple and transparent; please fill in the form below
Learn More & Get Started
Explore our joint offering with Eurofins Genomics and streamline your mRNA production workflow.
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What Happens During Production?
Here is how we turn your request into high-quality, functional mRNA:
Sequence Optimization (Optional): Eurofins can help refine your template if desired
DNA Production: Eurofins produces the plasmid DNA and ships it to baseclick
mRNA Synthesis: baseclick performs in vitro transcription and optional modifications
Quality Control: All products undergo thorough QC at baseclick
Shipping: We carefully prepare and ship your custom mRNA
Support: We are happy to follow up and assist with your experiments if needed -
Why It Matters
This seamless handoff between Eurofins and baseclick ensures:
- Faster turnaround times
- Reduced coordination effort on your side
- High-quality, ready-to-use mRNA tailored to your application
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Applications
- Therapeutic mRNA & cancer vaccines
- Diagnostics (e.g., synthetic RNA standards)
- Live-cell imaging and biodistribution tracking
- mRNA stability and uptake research
LITERATURE
[1] Chemoenzymatic Preparation of Functional Click-Labeled Messenger RNA, S. Croce et al., 2020, ChemBioChem, Vol. 21, p. 1641.
https://doi.org/10.1002/cbic.201900718
[2] 5-Ethynyluridine: a bio-orthogonal uridine variant for mRNA-based therapies and vaccines, S. Maassen et al., 2023, ChemBioChem, Vol. 24, p. e202200658.
https://doi.org/10.1002/cbic.202200658
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning, J. Luo, M. Molbay, Y. Chen, et al. 2025, Nat Biotechnol.
https://doi.org/10.1038/s41587-024-02528-1
Multiple covalent fluorescence labeling of eukaryotic mRNA at the poly(A) tail enhances translation and can be performed in living cells, L. Anhäuser et al., 2019, Nucleic Acids Research, Vol. 47, No. 7.
https://doi.org/10.1093/nar/gkz084
Multiplexed dendritic targeting of alpha calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathway, Y. Gao et al., 2008, Mol. Biol. Cell, 19, p. 2311–2327.
https://doi.org/10.1091/mbc.e07-09-0914
Dendritically localized transcripts are sorted into distinct ribonucleoprotein particles that display fast directional motility along dendrites of hippocampal neurons, F. Tübing et al., 2010 J. Neurosci., 30, p. 4160–4170.
https://doi.org/10.1523/JNEUROSCI.3537-09.2010
Drosophila wingless and pair-rule transcripts localize apically by dynein-mediated transport of RNA particles, G.S Wilkie and I. Davis, 2001 Cell, 105, p. 209–219.